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ARTreat targets at providing a patient-specific computational model of the cardiovascular system, used to improve the quality of prediction for the atherosclerosis progression and propagation into life-threatening events that need to be treated accordingly.

ARTreat will provide a three-level patient model describing the 3d arterial tree anatomy, the patient-specific blood flow and blood particle dynamics and the biological processes that lead to the creation and progression of atherosclerotic plaques.

ARTreat will apply the developed patient-specific model on two main applications: the clinical decision support and the training. ARTreat will produce two decision support tools to assist clinical cardiologists into providing personalized treatmentselection and real-time, on- the-fly advice during invasive interventions, such as stent positioning. The aim is to minimize future therapy costs, by providing higher than ever possible personalized treatment support. The same patient-specific model will also be used to develop a real-case simulator training, which will support realistic hands-on skill development training to clinical cardiologists.

Finally, ARTreat is coupled with advanced clinical support tools for plaque characterization, and the discovery of new knowledge; associations among heterogeneous data, that can improve the predictive power of the patient-model. It thus supports the medical expert into programming the accumulated knowledge into the existing model and generating an adaptive patient-specific computational tool.

Members of the ARTreat consortium include organisations which are among the European leading companies for products and services in the areas of (i) medical IT and (ii) cardiovascular and arterial surgery. Those companies will exploit the ARTreat applications to provide new sophisticated solutions to their product range, while all academic and IT company partners will accumulate significant experience on the new generation patient-specific healthcare service. 

 
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ARTreat Sub-Project 2:

Cardiovascular System: Patient-Specific Biological Processes Modelling

Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. Over the past decade, scientists come to appreciate a prominent role of inflammation in atherosclerosis.

In this ARTreat sub-project we are developing the continuum and discrete algorithms by comparing the results with our own experimental results and from literature.

1. ARTreat continuum module for plaque formation and development

2D and axi-symmetric geometry of stenosed arteries

3D geometry of stenosed arteries

2. ARTreat discrete module for plaque formation and development

Concerning lesion growth modeling, which is a complex phenomenon with events occurring at different time and space scales (genetic, cellular and the macroscopic level), we are developing three models:

Discrete particle dynamics

Cellular automata

Agent based model

 

3. ARTreat experimental research

Experiments are performed  under normal physiological conditions (control experiments), under condition of ischemia- reperfusion injury, and in various stages of atherosclerosis development. The aim is to evaluate relations between LDL transport parameters and biomechanical properties of isolated blood vessels during atherosclerosis development, as a basis for computational modelling and clinical application.

 
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